Impact of imbalanced PRA/PRB ratio on transcription of genes involved in breast cancer development and metastasis.

Transcriptional changes induced by lack of either PRA or PRB as compared to the pattern obtained in cells co-expressing PR isoforms at equimolar level and potentially enhancing tumor growth and/or metastatic evolution. HBEGF and AREG genes are underlined.

相较于以等摩尔水平共表达孕激素受体（Progesterone Receptor, PR）同工型的细胞所获得的基因表达谱，因缺失任一PRA或PRB所诱导的转录变化，或可促进肿瘤生长及/或转移演进。其中HBEGF与AREG基因已被下划线标注。