OPC_RN_LN_dataset.csv

Public anonymized data deposition for the publication: Spatially-aware clustering improves AJCC-8 risk stratification performance in oropharyngeal carcinomas; Guadalupe Canahuate, Andrew Wentzel, Abdallah S.R. Mohamed, Lisanne V. van Dijk, David M. Vock, Baher Elgohari, Hesham Elhalawani, Clifton D. Fuller, G. Elisabeta Marai. Oral Oncology, Volume 144, 2023, 106460. ISSN 1368-8375. https://doi.org/10.1016/j.oraloncology.2023.106460. https://www.sciencedirect.com/science/article/pii/S1368837523001562 <br> Description of data: Comprises as cohort of anonymized/deidentified data from 675 HPV+ OPC patients that were treated at MD Anderson Cancer Center between 2005 and 2013 with curative intent IMRT, retrospectively collected under IRB approval. Risk stratifications incorporating patient radiometric data and lymph node metastasis patterns via an anatomically-adjacent representation with hierarchical clustering were identified. These clusterings were combined into a 3-level patient stratification and included along with other known clinical features in a Cox model for predicting survival outcomes, and logistic regression for toxicity, using independent subsets for training and validation.

本公开匿名数据集关联发表论文：《空间感知聚类提升口咽癌患者美国癌症联合委员会第8版（AJCC-8）风险分层效能》；作者：Guadalupe Canahuate、Andrew Wentzel、Abdallah S.R. Mohamed、Lisanne V. van Dijk、David M. Vock、Baher Elgohari、Hesham Elhalawani、Clifton D. Fuller、G. Elisabeta Marai。该论文发表于《口腔肿瘤学》（Oral Oncology）2023年第144卷，文章编号106460，ISSN：1368-8375。官方DOI链接：https://doi.org/10.1016/j.oraloncology.2023.106460，ScienceDirect原文链接：https://www.sciencedirect.com/science/article/pii/S1368837523001562。数据集概况：本数据集为经机构审查委员会（Institutional Review Board, IRB）批准回溯收集的匿名化/去标识化队列数据，纳入2005至2013年间在MD安德森癌症中心接受根治性调强放射治疗（Intensity-Modulated Radiation Therapy, IMRT）的675例HPV阳性口咽癌（HPV-positive oropharyngeal carcinoma, HPV+ OPC）患者。研究通过基于解剖邻近性表征的层次聚类方法，结合患者放射学数据与淋巴结转移模式构建风险分层方案；将聚类结果整合为三级患者风险分层体系，并与其他已知临床特征一同纳入Cox比例风险模型以预测生存结局，同时采用独立子集进行训练与验证，构建用于毒性预测的逻辑回归模型。