Latexin regulates hematopoiesis in a sex-dependent manner by differential expression of sex chromosome-specific microRNA 98-3p and thrombospondin 1

To investigate the molecular mechanism underlying gender-specific regulation of hematopoiesis by Lxn. RNA sequencing was performed on LSK cells that were isolated from male and female WT and Lxn-/- mice. Comparative gene expression profiling analysis of RNA-seq data for male WT, male Lxn-/-, female WT, and female Lxn-/-.

为探究Lxn调控造血过程的性别特异性分子机制，本研究从雄性与雌性野生型（Wild Type, WT）、Lxn基因敲除（Lxn-/-）小鼠中分离得到LSK细胞并进行RNA测序（RNA sequencing, RNA-seq）；随后针对雄性野生型、雄性Lxn-/-、雌性野生型及雌性Lxn-/-样本的RNA-seq数据，开展了比较基因表达谱分析。