2D/3D coordination polymers: treatment effect on the ulcerative colitis by reducing the inflammatory response

Two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L₁)(bdc)](H₂O)}_n (<b>1</b>, L₁ = 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene, H₂bdc = terephthalic acid) and {[Co(L₂)(bdc)](H₂O)}_n (<b>2</b>, L₂ = 1,3-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene) have been successfully prepared by the solvothermal treatment of H₂bdc and different N-donor co-ligands with Co(II) salt. In biological functional study, the treatment effect of compounds <b>1</b> and <b>2</b> on the ulcerative colitis (UC) was evaluated. Firstly, the ELISA assay was performed to reveal the changes of the inflammatory cytokines caused by compounds. Besides, the model of mice was established and the mice' body weight was measured and recorded at the 7th and 14th day after compounds treatment.

本研究以对苯二甲酸（H₂bdc）、不同氮供体共配体与二价钴盐为原料，通过溶剂热法成功制备了两种新型混合配体配位聚合物，其化学式分别为{[Co(L₁)(bdc)](H₂O)}ₙ（化合物1，其中L₁为1,4-双((1H-苯并[d]咪唑-1-基)甲基)苯，H₂bdc为对苯二甲酸）与{[Co(L₂)(bdc)](H₂O)}ₙ（化合物2，其中L₂为1,3-双((1H-苯并[d]咪唑-1-基)甲基)苯）。在生物学功能研究中，本研究评估了化合物1与2对溃疡性结肠炎（ulcerative colitis, UC）的治疗效果。首先通过酶联免疫吸附测定（enzyme-linked immunosorbent assay, ELISA）实验，揭示了化合物处理后炎性细胞因子的水平变化；此外，构建了溃疡性结肠炎小鼠模型，并在给药后第7天和第14天称量并记录小鼠体重。