c-MYC drives a subset of high-risk pediatric neuroblastomas and is activated through mechanisms including enhancer hijacking and focal enhancer amplification [RNA-seq]

Childhood neuroblastoma is known for MYCN gene amplification, and here we show that in a separate subset of cases MYC-itself is activated due to enhancer hijacking from chromosomal translocations or duplications, thus defining a unique subset of high-risk disease. Overall design: RNA-seq in zebrafish overexpressing human c-Myc or n-Myc儿童神经母细胞瘤（Childhood neuroblastoma）以MYCN基因扩增为典型特征，本研究发现，在独立亚组的病例中，MYC基因本身可因染色体易位或重复引发的增强子劫持（enhancer hijacking）而激活，由此界定了一类独特的高危疾病亚组。实验设计概述：对过表达人源c-Myc或n-Myc的斑马鱼开展RNA测序（RNA-seq）。