Replication Data for: Long-term dietary intervention with low Phe and/or a specific nutrient combination improve certain aspects of brain functioning in Phenylketonuria (PKU)

<p>48 Homozygous wild-types (WT, +/+) and 96 PKU BTBRPah2 (-/-) male and female mice started dietary treatment on postnatal day 31 up to 10 months of age in the following six groups: WT control diet (WT C-HP), WT normal diet plus specific nutrient combination (WT SNC-HP), PKU normal diet (PKU C-HP), PKU normal diet plus specific nutrient combination (PKU SNC-HP), PKU low-Phe diet (PKU C-LP), and PKU low-Phe diet plus specific nutrient combination (PKU SNC-LP).</p>
<p>Mice were tested three times (4,7, and 10 months) after treatment initiation during four behavioural tasks: open field (OF), novel object recognition task (NOR), spatial object recognition task (SOR), and balance beam task (BB).</p>
<p>The results are stored in three zipped folders:</p>
<ul>
<li>Measurements.zip: Excel files with the results of the various behavioral tasks at 4, 7 and 10 months of age</li>
<li>StatisticalAnalyses.zip: SPSS files (.sav) of the various behavioral tasks</li>
<li>Neurotransmitters: Results and statistical analysis of the various neurotransmitter levels per mouse</li>
</ul>

48只纯合野生型（Homozygous wild-types, WT, +/+）小鼠与96只苯丙酮尿症（PKU）BTBRPah2 (-/-)雌雄小鼠，于出生后第31天启动饮食干预，持续至10月龄，共分为以下6组：WT对照高苯丙氨酸饮食组（WT C-HP）、WT正常饮食联合特定营养组合组（WT SNC-HP）、PKU正常饮食组（PKU C-HP）、PKU正常饮食联合特定营养组合组（PKU SNC-HP）、PKU低苯丙氨酸饮食组（PKU C-LP）以及PKU低苯丙氨酸饮食联合特定营养组合组（PKU SNC-LP）。在干预启动后的第4、7、10月龄，对小鼠开展3次行为学测试，涵盖4项行为学任务：旷场实验（open field, OF）、新物体识别任务（novel object recognition task, NOR）、空间物体识别任务（spatial object recognition task, SOR）与平衡木实验（balance beam task, BB）。所有实验结果存储于3个压缩文件夹中：1. Measurements.zip：包含4、7、10月龄各行为学测试结果的Excel文件；2. StatisticalAnalyses.zip：包含各项行为学测试的SPSS数据文件（.sav格式）；3. Neurotransmitters：各小鼠神经递质水平的检测结果及对应的统计学分析数据。