Control of eukaryotic transcription elongation

The Spt4, Spt5, and Spt6 proteins are conserved eukaryotic transcription-elongation factors. Recent studies have provided the first evidence that they are generally required in multicellular eukaryotes, including during development and for viral gene expression.Spt4、Spt5与Spt6蛋白属于保守的真核转录延伸因子（transcription-elongation factors）。近期研究首次提供直接证据，证实这类因子在多细胞真核生物中普遍不可或缺，既参与生物体发育进程，也对病毒基因表达具有必要性。