基于高分子柔性材料刺激响应性器件的药物装载与释放数据集

在精准和个性化医学的有效药物治疗中，将合适的药物以正确的剂量和最佳时间给合适的患者至关重要。最佳药物给药速度可确保药物在血液中达到其目标浓度，从而在最大化疗效的同时将毒性风险降至最低。此外，它有助于维持稳定的药物水平，避免可能导致疗效不佳或副作用的波动。因此，精确控制药物给药速度对于实现预期的治疗目标至关重要。而随着柔性电子技术的发展，用于生物医学的集成电子器件为药物的控制释放和输送提供了新的解决方案。本整合数据集采用“器件/材料构筑与表征—药物装载与体外释放定量—刺激响应行为评估—细胞与动物水平生物学验证—数据结构化整理与统计分析”的采集流程。建立了柔性电子主动控释给药器件数据集、自组装高分子纳米颗粒药物可控释放数据数据集、超声响应水凝胶分段药物释放数据集和镓合金液态金属载药敷料数据集。本数据集为解释柔性材料与药物释放之间的构效关系，以及构建相关的评价方法等方面具有参考意义。

In effective pharmacotherapy for precision and personalized medicine, it is critical to administer the right drug to the right patient at the correct dosage and optimal timing. An optimal drug administration rate ensures that the drug reaches its target concentration in the bloodstream, thereby maximizing therapeutic efficacy while minimizing the risk of toxicity. Furthermore, it helps maintain stable drug levels and avoids fluctuations that could lead to suboptimal therapeutic outcomes or adverse side effects. Thus, precise control over drug administration rate is essential for achieving the desired therapeutic goals.

With the advancement of flexible electronics, integrated electronic devices for biomedical applications have provided novel solutions for controlled drug release and delivery. This integrated dataset follows a data acquisition workflow comprising five stages: fabrication and characterization of devices and materials, quantitative analysis of drug loading and in vitro drug release, evaluation of stimuli-responsive behavior, biological validation at cellular and animal levels, and structured data organization and statistical analysis. Four specific datasets have been constructed, including a dataset of flexible electronic active controlled-release drug delivery devices, a dataset of controlled drug release from self-assembled polymeric nanoparticles, a dataset of segmented drug release from ultrasound-responsive hydrogels, and a dataset of gallium alloy liquid metal drug-loaded dressings.

This dataset offers valuable references for explaining the structure-activity relationship between flexible materials and drug release, as well as for developing relevant evaluation methods.