Hnf4 controls gut and liver gene programs in the thymus [CUT&Tag]. Hnf4 controls gut and liver gene programs in the thymus [CUT&Tag]

We profiled medullary thymic epithelial cells and intestinal epithelial cells by CUT&Tag to investigate mechanisms of T-cell tolerance. Overall design: CUT&Tag of mTECs and IECs本研究采用CUT&Tag技术（Cleavage Under Targets and Tagmentation）对胸腺髓质上皮细胞（medullary thymic epithelial cells）与肠上皮细胞（intestinal epithelial cells）开展表观遗传图谱分析，旨在揭示T细胞耐受的作用机制。实验整体设计：针对胸腺髓质上皮细胞与肠上皮细胞的CUT&Tag检测。