Gene expression profiling of aortic media after long-term treatment with an angiotensin II-receptor blocker, Losartan

Rats (Wag/Rij, females) were chronically treated with Losartan (20mg/d), an angiotensin II-receptor blocker during 9 months. Gene expression profiling was performed on aortic media to understand the long-term effect of this molecule on the cardiovascular system.对雌性Wag/Rij品系大鼠以20mg/日的剂量给予氯沙坦（Losartan）——一种血管紧张素II受体拮抗剂（angiotensin II-receptor blocker），持续给药9个月。研究人员对大鼠主动脉中膜组织开展基因表达谱分析，以探究该分子对心血管系统的长期影响。