Genome-wide DNA Microarray Unravels Rapid Changes in the Transcriptome of MK-801 treated Rat Brain

Conclusions: Our results reveal that MK-801 triggered i) an increase in the power of gamma oscillations, and ii) simultaneously caused very early changes in gene expressions in the rat brain, representing a first such inventory of gene expression profiles in brain after acute MK-801 treatment.结论：本研究结果显示，地佐环平（MK-801）可诱发两种效应：一是伽马振荡（gamma oscillations）的功率显著升高；二是同时引发大鼠脑内极早期的基因表达改变。本研究为急性MK-801给药后大鼠脑内基因表达谱的首次此类编目。