Crystal Structure of HIV-1 PRS17 with GRL-142
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Crystal Structure of HIV-1 PRS17 with GRL-142 Descriptor: (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, CHLORIDE ION, GLYCEROL, ... Authors: Agniswamy, J, Weber, I.T. Deposit date: 2021-05-22 Release date: 2021-07-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR S17 . Biochem.Biophys.Res.Commun., 566, 2021
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2021-05-22
