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Homo sapiens spCas9 off-target NGS raw sequence reads

NIAID Data Ecosystem2026-03-12 收录

CRISPR脱靶效应

基因编辑安全性

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA666282 数据链接链接失效反馈

官方服务：

资源简介：

Targeted endogenous loci mKate knock-in off-target sequencing in human embryonic kidney cell line

应用场景：

创建时间：

2020-09-29

通用型CAR-T疗法

基因编辑安全性

Autologous T cells expressing the Chimeric Antigen Receptor (CAR) have been approved as advanced therapy medicinal products (ATMPs) against several hematological malignancies. However, the generation

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A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

CRISPR脱靶效应

基因组编辑特异性

Clustered regularly interspaced short palindromic repeat (CRISPR) RNA-guided nucleases have gathered considerable excitement as a tool for genome engineering. However, questions remain about the speci

NIAID Data Ecosystem30

Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites

基因编辑安全性

逆转录转座子转录

CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology and entered the clinical world for targeted gene therapy. Identifying DNA modifications occurring at CRISPR/Cas9 targ

NIAID Data Ecosystem20

Supplemental Material for Fernandez et al., 2019

基因编辑DNA修复分析

CRISPR脱靶效应

This Supplemental Data set includes raw data utilized for the TIDE (Tracking across Indels by DEcomposition) method. Supplemental Table S1 provides raw data for the proportion of NHEJ with end process

NIAID Data Ecosystem30

on- and off-target analysis

基因组编辑评估

CRISPR脱靶效应

Comprehensively on- and off-target analysis using targeted deep sequencing

NIAID Data Ecosystem20