Expression data from pancreatic beta cells isolated from differentially weaned mice.

Transcriptome analysis reveals that in pancreatic beta cells weaning increases the expression of genes involved in replication licensing, suggesting a mechanism to increased responsiveness to the mitogenic activity of high glucose. β cells were sorted from dissociated islets of P25 insulin-Cre; Rosa26-LSL-YFP mice (Gannon et al., 2000; Srinivas et al., 2001) that were either suckling or prematurely weaned at P18. YFP+ FACS-sorted cells were subjected for RNA extraction and hybridization on Affymetrix microarrays