Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Quade, B, Huang, X. Deposit date: 2024-03-06 Release date: 2024-04-17 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (2.07 Å) Cite: The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024