MLKL Activates cGAS-STING Pathway by Releasing Mitochondrial DNA Upon Necroptosis Induction. Ding et al

Mendeley Data2026-04-09 收录

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cGAS-STING通路激活

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These data were conected with "MLKL Activates cGAS-STING Pathway by Releasing Mitochondrial DNA Upon Necroptosis Induction" by Ding et al.

Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis

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HIV-1 glycoprotein gp120 induces injury and apoptosis in rodent and human neurons in vitro and in vivo and is therefore thought to contribute to HIV-associated dementia. In addition to CD4, different

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Intracellular bacteriolysis contributes to pathogenicity of Staphylococcus aureus by exacerbating AIM2-mediated inflammation and necroptosis

细胞内感染免疫

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Staphylococcus aureus can survive within phagocytes. Indeed, we confirm in this study that approximately 10% of population persists in macrophages during S. aureus infection, while the r

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靶向蛋白降解

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Proteolysis targeting chimera (PROTAC) recruits an E3 ligase to a target protein to induce its ubiquitination and subsequent degradation. We reported success in the development of two PROTACs (C3 and

NIAID Data Ecosystem50

Single cell RNAseq of iPSC tri-cultures treated with necroptosis inducer. Single cell RNAseq of iPSC tri-cultures treated with necroptosis inducer

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神经退行性疾病分子研究

Transcriptomic analysis of iPSC tri-culture (microglia, neurons, astrocytes) stimulated with Tnf, Smac, and Zvad (TSZ) to trigger necroptosis pathway activation, in the presence or absence of a Ripk1

NIAID Data Ecosystem70

A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells

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Necroptosis has been recently confirmed as a non-apoptotic form of programmed cell death. Discovery of novel chemical entities, capable of inducing necroptosis of cancer cells, is likely to act as an

NIAID Data Ecosystem50

MLKL Activates cGAS-STING Pathway by Releasing Mitochondrial DNA Upon Necroptosis Induction. Ding et al

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