Comparison of brown adipose tissue (BAT) gene expression between Letmd1 KO and wild-type control mice housed at 30C or 7C for 3 weeks.

We identified Letm1 domain containing 1 (Letmd1) as a candidate regulator of BAT thermogenesis. We generated Letmd1 KO mice, raised at thermoneutral or cold conditions, and performed RNA-sequencing in BAT. Transcriptome profiles of BAT of adult Letmd1 KO and wild-type mice housed at 30C or 7C for 3 weeks.本研究鉴定出含Letm1结构域1（Letmd1）为棕色脂肪组织（Brown Adipose Tissue，BAT）产热的潜在调控因子。我们构建了Letmd1基因敲除（Knockout，KO）小鼠，分别在热中性环境与低温条件下饲养，并对其棕色脂肪组织进行了RNA测序（RNA-sequencing）。本数据集包含在30℃或7℃环境中饲养3周的成年Letmd1基因敲除小鼠与野生型小鼠的棕色脂肪组织转录组谱。