DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-induced Leukemogenesis in vivo

ChEBI2012-04-21 更新2026-07-21 收录

白血病发病机制

DNA损伤反应与炎症信号

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-35038 数据链接链接失效反馈

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DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-induced Leukemogenesis in vivo

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2012-04-21

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia (RNA-seq of KLF6 KO)

造血干细胞表观遗传学

白血病发病机制

Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and trans

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白血病发病机制

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Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

NIAID Data Ecosystem30

Gene expression profiling of CA10 and NHD13 murine AML

急性髓系白血病基因表达谱

白血病发病机制

We have compared the gene expression profiles of leukemic tissues in two different mouse models of AML, CALM-AF10 and NHD13, to clincally healthy transgenic and wildtype hematopoetic tissue to identif

Alliance of Genome Resources50

Transcriptional profiling (SMARTer-Seq) has been performed on CD48-/CD48+ LSK hematopoietic cells to determine the effect introduced by the abrogation of Sbds within mesenchymal cells.

白血病发病机制

间质-造血细胞互作

Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system but the molecular mechanisms and their relevance to human disease remain poorly defined Here,

NIAID Data Ecosystem30

DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-induced Leukemogenesis in vivo

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