magnoflorine alter gut RNA-seq in mice colitis

Magnoflorine, a naturally occurring small molecule compound, exhibits a remarkable profile of biological activities, including non-toxicity, anti-inflammatory properties, and anxiolytic effects. In the present study, we found that magnoflorine not only improved the intestinal barrier and alleviates colitis, but also improved the blood-brain barrier as well as neuroinflammation, which in turn reduced colitis-induced anxiety behaviours