Isolation of Ugi Four-Component Condensation Primary Adducts: A Straightforward Route to Isocoumarins
收藏NIAID Data Ecosystem2026-03-06 收录
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Ugi four-component condensation (Ugi-4CC) between 2-formylbenzoic acid, phenacylamine dimethyl acetal, and isocyanides afforded 1H-isochromen-1-ones (isocoumarins). These products, where structure corresponds to the tautomeric enediamine form of the Ugi-4CC primary adducts, were stable enough to allow their isolation and characterization. Stable isocoumarins were also obtained by employing anilines as the amino component in the Ugi four-component condensation.
创建时间：
2010-02-19
