Expression data from mouse intestinal organoids II. Mus musculus
收藏NIAID Data Ecosystem2026-03-09 收录
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APC inactivation is the early process in the tumorigenesis of colorectal cancer. We established organoid cultures from intestines of genetically modifeid mice harboring Apcfl/fl, Tacc3wt/wt or Apcfl/fl, Tacc3fl/fll and R26CreERT2 allele We used microarrays to determine the alterations in intestinal stem cells in response to Tacc3 disruption. Overall design: Organoids were treated with 4OHT to induce recombination of APC and Tacc3, and collected at 4 or 6 days after treatment. RNA were extracted and hybridization on Affymetrix microarrays.
创建时间：
2016-01-13
