Supporting Information for fluralaner binding in GABAR

Fluralaner is a novel isoxazoline insecticide with broad insect spectrum, and mainly acts on the insect GABA receptor with unique binding action. The potential binding residues were predicted by SYBYL-X 2.1 software, and verified respectively by the site-directed mutagenesis and two-electrode voltage clamp (TEVC) technique. The data include the primers used in our study, and result of electrophysiological, et,al.