Cohesin mutations in AML
收藏kaggle2023-01-06 更新2024-03-08 收录
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2023-01-06
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Cohesin Mutations in AML
Cohesin shapes the nuclear chromatin architecture, including enhancer-promoter interactions, and its components, of which especially STAG2 and RAD21, are frequently mutated in myeloid malignancies. To
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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML. Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML
The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer includin
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Depletion of Rad21 in murine bone marrow leads to enhanced self-renewal in vitro Bone marrow was extracted from mice, infected with lentiviruses encoding shRNAs to Rad21, and cultured in methylcellulo
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Depletion of Rad21 in murine bone marrow leads to enhanced self-renewal in vitro Overall design: Bone marrow was extracted from mice, infected with lentiviruses encoding shRNAs to Rad21, and cultured
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