To establish a productive infection in new host species, viruses must overcome barriers mediated by diverse and rapidly evolving host restriction factors such as protein kinase R (PKR). To model the p
Viruses continually adapt to evade host immune defenses. To understand how poxviruses adapt to strong selective pressure imposed by innate immune detection pathways, we performed experimental evolutio
Transcription of the vaccinia virus genome is mediated by a virus-encoded multisubunit DNA-dependent RNA polymerase in conjunction with early-, intermediate-, and late-stage-specific factors. Previous