Vaccinia Virus Copenhagen Transcription Anlaysis

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https://www.ncbi.nlm.nih.gov/sra/SRP144966

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Vaccinia Virus transcriptome analysis post HeLa cell infection

创建时间：

2018-05-10

Vaccinia Virus Copenhagen Transcription Anlaysis

Vaccinia Virus transcriptome analysis post HeLa cell infection

NIAID Data Ecosystem20

Vaccinia virus strain:Copenhagen VVdelEdelK+RhTRS1 Genome sequencing

To establish a productive infection in new host species, viruses must overcome barriers mediated by diverse and rapidly evolving host restriction factors such as protein kinase R (PKR). To model the p

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Vaccinia virus evolution reveals adaptations to evade host viral nucleic acid sensing. Orthopoxvirus vaccinia strain:Copenhagen

Poxviruses are large DNA viruses that rapidly adapt to hosts despite a relatively low mutation rate. One mechanism for adaptive evolution is through transient copy number variation described as ‘gene

NIAID Data Ecosystem30

High frequency single nucleotide changes and copy number amplification support rapid evolution of vaccinia virus. Vaccinia virus Copenhagen

Viruses continually adapt to evade host immune defenses. To understand how poxviruses adapt to strong selective pressure imposed by innate immune detection pathways, we performed experimental evolutio

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Vaccinia virus Post replicative transcription start sites.. Orthopoxvirus vaccinia

Pervasive Initiation and 3’ End Formation of Poxvirus Post-Replicative RNAs. Vaccinia virus expressed in Hela cells.

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