Combination marker performance.

a)Sens98 = Sensitivity at 98% specificity in discriminating cases from all controls (Healthy Controls, Surgical Benigns and Surgical Normals). b)AUC = Area Under (ROC) Curve for discriminating cases from all controls (Healthy Controls, Surgical Benigns and Surgical Normals). c)P-value for the best available two-marker combination compared to the best available three-marker combination (see Materials and Methods).