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Upregulation of CD11A on hematopoietic stem cells denotes the loss of long-term reconstitution potential

ChEBI2014-10-22 更新2026-07-21 收录

造血干细胞功能

干细胞再生能力评估

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-60597 数据链接链接失效反馈

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Upregulation of CD11A on hematopoietic stem cells denotes the loss of long-term reconstitution potential

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创建时间：

2014-10-22

造血干细胞功能

Jak-STAT信号通路

Previous studies have illustrated the importance of Jak1-mediated cytokine signaling in immunological and neoplastic diseases such that JAK1 inhibition is currently being investigated in clinical tria

NIAID Data Ecosystem60

STAT1 is essential for hematopoietic stem cell function and maintains a MHC IIhi stem cell subset that resists myeloablation and neoplastic expansion [LK]

造血干细胞功能

STAT1基因

Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal mediator of interferon (I

NIAID Data Ecosystem40

Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

白血病淋巴瘤分子机制

造血干细胞功能

Expression data from control and LRF (leukemia/lymphoma related factor)-deficient mouse LT-HSCs

ChEBI2012-10-26 更新10

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Mus musculus

骨髓增生异常综合征小鼠模型

造血干细胞功能

Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on

NIAID Data Ecosystem40

5G2 Mutant Mice Model Loss of a Commonly Deleted Segment of Chromosome 7q22 in Myeloid Malignancies

骨髓增殖性肿瘤遗传学

造血干细胞功能

Monosomy 7 and del(7q) are among the most common and poorly understood genetic alterations in myelodysplastic neoplasms and acute myeloid leukemia. Chromosome band 7q22 is a minimally deleted segment

NIAID Data Ecosystem20

Upregulation of CD11A on hematopoietic stem cells denotes the loss of long-term reconstitution potential

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