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ROR-Î³ drives androgen-receptor expression and represents a therapeutic target in castration-resistant prostate cancer

ChEBI2016-03-08 更新2026-07-12 收录

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数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-72483 数据链接链接失效反馈

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资源简介：

ROR-Î³ drives androgen-receptor expression and represents a therapeutic target in castration-resistant prostate cancer

应用场景：

创建时间：

2016-03-08

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表观遗传靶点

Androgen deprivation therapy (ADT) is the standard care for prostate cancer patients who fail surgery and radiotherapy. While initially effective, the cancer almost always recurs into a more aggressiv

NIAID Data Ecosystem100

ARv7 represses tumor suppressors genes in castration-resistant prostate cancer [RNA-Seq]

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转录抑制机制

Endocrine therapies in prostate cancer (PCa) treatment block androgen receptor (AR) function, but are palliative as tumors progress to a lethal, castration-resistant state (CRPC). CRPC remains depende

NIAID Data Ecosystem50

Targeting Wnt5A and SRC1 in prostate cancer with siRNA

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siRNA基因沉默

We investigated the role of Wnt5A and SRC1 in castration-resistant prostate cancer cells using corresponding siRNA. LNCaP-abl (Abl) cells were transfected with siRNA against Wnt5A or SRC1 or non-targe

NIAID Data Ecosystem20

Phenotypic characterization of two novel cell line models of castration resistant prostate cancer

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癌症耐药机制研究

Purpose: Resistance to androgen deprivation therapies is a major driver of mortality in advanced prostate cancer. Therefore, there is a need to develop new pre-clinical models that allow the investiga

NIAID Data Ecosystem50

Human prostate cancer cells (VCaP and AIVCaP): siAR alone (single siRNA) vs. siAR plus OPRK1 (combo-siRNA)

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OPRK1基因功能

Through comparative genomics using PDX models of androgen-dependent (AD) and castration-resistant (CR) tumors, we identify opioid receptor kappa 1 (OPRK1) as being associated with castration-resistanc

NIAID Data Ecosystem30

ROR-Î³ drives androgen-receptor expression and represents a therapeutic target in castration-resistant prostate cancer

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