Massively parallel CRISPR-Cas binding assays
收藏NIAID Data Ecosystem2026-04-25 收录
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资源简介：
Most CRISPR-Cas systems suffer from off-target effects and unpredictable non-specific binding that negatively impact their reliability and broader applicability. To better evaluate the impact of mismatches on DNA target recognition and binding affinities, we develop a massively parallel CRISPR interference (CRISPRi) assay called Xseq to measure the affinity between tens of thousands of CRISPR RNA (crRNA) and target DNA sequences.
创建时间：
2019-06-26
