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Cas9 target DNA specificity
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创建时间：
2014-11-14
相关数据集
Homo sapiens Targeted Locus (Loci). Homo sapiens
To evaluate the DNA cleavage specificity of fCas9, we measured the modification of Cas9 off-target sites of CLTA, EMX, and VEGF genomic target sites. The target site and its corresponding known off-ta
NIAID Data Ecosystem80
Genome-wide Profiling of Adenine Base Editor Specificity by EndoV-seq. Homo sapiens
EndoV-seq utilizes Endonuclease V (EndoV) to nick the inosine (I)-containing DNA strand of genomic DNA that has been deaminated by ABE in vitro. The treated DNA is then whole-genome sequenced to ident
NIAID Data Ecosystem60
sgRNA library with comprehensive mismatch
The library of two sgRNAs with the comprehensive single or double mismatches. See Thesis chapter 5.
Figshare2020-03-27 更新50
Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2. Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2
We present GuideScan2 for memory-efficient, parallelizable construction of high-specificity CRISPR guide RNA (gRNA) databases and user-friendly design and analysis of individual gRNAs and gRNA librari
NIAID Data Ecosystem70
Genome-wide analysis of base editing specificity in human iPSCs
Targeting specificity of genome editing tools is crucial for their applications in research and medicine. This project studies the specificity of cytosine base editor in human induced pluripotent stem
NIAID Data Ecosystem60
