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Cas9 target DNA specificity
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创建时间：
2014-11-14
相关数据集
CRISPR GUARD: short guide RNAs protect off-target sites from Cas9 nuclease activity
Precise genome editing using CRISPR-Cas9 driven nucleases and base editors are promising therapeutic avenues for genetic diseases, although collateral damage caused by off-targets is a significant saf
NIAID Data Ecosystem40
Genome-wide Profiling of Adenine Base Editor Specificity by EndoV-seq. Homo sapiens
EndoV-seq utilizes Endonuclease V (EndoV) to nick the inosine (I)-containing DNA strand of genomic DNA that has been deaminated by ABE in vitro. The treated DNA is then whole-genome sequenced to ident
NIAID Data Ecosystem30
Targeting G with TAL Effectors: A Comparison of Activities of TALENs Constructed with NN and NK Repeat Variable Di-Residues
The DNA binding domain of Transcription Activator-Like (TAL) effectors can easily be engineered to have new DNA sequence specificities. Consequently, engineered TAL effector proteins have become impor
Figshare2016-01-19 更新30
Suppression of unwanted CRISPR/Cas9 editing by co-administration of catalytically inactive truncated guide RNAs. Homo sapiens
The goal of this study is to develop a novel method for reducing unwanted genomic editing by CRISPR/Cas9 and improve specificity in a variety of cellular contexts.
NIAID Data Ecosystem40
SpCas9 with 17-bp R-loop containing 2 terminal mismatches (State II - precleavage)
SpCas9 with 17-bp R-loop containing 2 terminal mismatches (State II - precleavage)
NIAID Data Ecosystem30
