Performance of the classifiers illustrated by confusion matrices of the prediction of IVIG binding on the test set.

aTraining sets consist of either three times more “non-binding” than “binding” peptides (original) or an equal number of both groups (balanced). bOur classifiers (ML-advanced, PWM with treshold 2.45; see Figure 1 for workflow) and the classifier of El-Manzalawy et al. [22][23]. cCorrect predictions are underlined. dnot determined.