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Use of N−N Bond Stereodynamics in Ring-Closing Metathesis to Form Medium-Sized Rings and Macrocycles

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NIAID Data Ecosystem2026-03-06 收录
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A unique strategy based on double ring-closing metathesis for the formation of a 14-membered macrocyclic enamide has been developed. This strategy hinges upon the well-known stereodynamic and conformational behavior of N-substituted diacylhydrazines, which promotes an effective ring-closing metathesis of hydrazine-derived dienes and enynes to form 8- to 14-membered rings.

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2004-11-11
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