Transition-Metal-Free Carbofluorination of TBS-Protected Nitrogen-Containing Cyclic Enynols: Synthesis of Fluorinated Azabicycles
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https://figshare.com/articles/dataset/Transition_Metal_Free_Carbofluorination_of_TBS_Protected_Nitrogen_Containing_Cyclic_Enynols_Synthesis_of_Fluorinated_Azabicycles/2407888
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资源简介：
The synthesis of fluorinated azabicycles
from tert-butyldimethylsilyl-protected N-containing cyclic
enynols using inexpensive BF3·OEt2 is described.
In this reaction, BF3 reacts as both the Lewis acid and
the fluoride source for cyclization/fluorination of the TBS-protected
cyclic N-containing enynols. The method provides
an easy access to fluorinated azabicycles where a new C(sp2)–F bond and a new bicyclic skeleton are generated at ambient
temperature within 1–13 min under metal-free reaction conditions.
创建时间：
2016-02-19
