Accelerated Midlife Endocrine and Bioenergetic Brain Aging in APOE4 Female Mice

Age, female sex and APOE4 genotype are top Alzheimer's risk factors. Using a translational perimenopause mouse model based on STRAW criteria, we investigated APOE genotype impact on female midlife endocrine aging. Overall design: Hippocampal gene expression data of APOE3 and APOE4 female mice across different chronological and endocrinological aging groups.