Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature d

NIAID Data Ecosystem60

Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

白血病发病机制

基因治疗研究

The MLL-ELL fusion gene results from the translocation t(11;19)(q23;p13.1) that is associated with de novo and therapy-related acute myeloid leukemia. To study its transforming properties, we retrovir

PubMed Central2000-09-19 更新40

Mus musculus Raw sequence reads (AAV9-S100A9-shRNA). Mus musculus strain:C57

基因治疗研究

RNA干扰机制

AAV9-S100A9-shRNA vs AAV9-control

NIAID Data Ecosystem70

Porcine Model of Hemophilia A

血友病A猪模型

基因治疗研究

Hemophilia A is a common X chromosome-linked genetic bleeding disorder caused by abnormalities in the coagulation factor VIII gene (F8). Hemophilia A patients suffer from a bleeding diathesis, such as

NIAID Data Ecosystem40