Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein

Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein Descriptor: 4-({2-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... Authors: Shenming, H, Mengyao, X, Lei, L, Yang, D, Sheng, C, Jinpeng, S. Deposit date: 2023-03-03 Release date: 2024-01-10 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023