RNA-seq analysis of cRel+/+ and cRel-/- Tregs

cRel is a transcription factor critical for the development of Tregs in the thymus. We examined the impact the lack of cRel has on Tregs at different stages of ontogeny (thymic pre-Tregs, thymic 'de novo' Tregs and mature spenic Tregs). mRNA expression was examined in Tregs at various life stages from cRel+/+ or cRel-/- mice.cRel是一种在胸腺中调控调节性T细胞（regulatory T cells，简称Tregs）发育的关键转录因子。本研究探究了cRel缺失对不同个体发育阶段的Tregs的影响，涵盖胸腺前调节性T细胞、胸腺新生调节性T细胞以及成熟脾脏调节性T细胞。我们还检测了来自cRel野生型（cRel+/+）与cRel敲除型（cRel-/-）小鼠不同生命阶段的Tregs的mRNA表达水平。