Antidepressant Mechanism of Acorus tatarinowii Volatile Oil via Inhibition of Microglial Polarization Through the TNF/NF-κB/NLRP3 Signaling Pathway

This dataset is used for transcriptome sequencing technology to screen key differentially expressed genes in VOA antidepressant treatment and perform pathway enrichment analysis. Visualization analysis is performed on a bioinformatics platform. In vitro and in vivo experiments were conducted using Western Blot to detect the expression levels of TNF/NF - κ B/NLRP3 pathway proteins (p-NF - κ Bp65/NF - κ Bp65, p-I κ B α/I κ B α, TNF - α, PTGS2, NLRP3, Caspase-1, IL-1 β) and microglial M1/M2 phenotype markers (CD16/32, CD206). Data analysis and statistical graphs were performed using GraphPad Prism 9.