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CRISPR off-target identification by in vitro method

NIAID Data Ecosystem2026-03-14 收录

CRISPR脱靶检测

基因预测模型

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA947384 数据链接链接失效反馈

官方服务：

资源简介：

Massively parallel CRISPR off-target detection enables rapid off-target prediction model building

应用场景：

创建时间：

2023-03-22

个体化癌症治疗

基因预测模型

593 FFPE colorectal cancer samples were used to generate three prediction models: Recurrence prediction, 5FU efficacy prediction, and FOLFOX efficacy prediction The recurrence prediction study has 235

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Additional file 3 of Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity

CRISPR脱靶检测

高通量测序

Additional file 3: Supplementary Data 2. Nano-OTS results for ATXN10, MMP14 and NEK1.

Figshare2020-12-02 更新10

Detection of off-target sites in the AAVS1 site

CRISPR脱靶检测

基因编辑安全性

To examine whether there were off-target effects in the 293T cell genome, we identified other potential off-target sgRNA sequences for Cas9 [27]. These off-target sequences all end before the NGG base

Figshare2024-10-23 更新10

Number of GUIDE-seq datasets and identified digested sequences. The numbers in the parentheses include technical replicates.

CRISPR脱靶检测

基因编辑序列分析

Number of GUIDE-seq datasets and identified digested sequences. The numbers in the parentheses include technical replicates.

Figshare2025-07-18 更新20

Raw files (Billon et al, Cell Reports, 2020)

基因编辑验证

CRISPR脱靶检测

Sanger sequencing files for ICE and EditR analyses Raw gel images and qPCR data for DTECT

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