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Copper-Catalyzed Enantioselective Propargylic Etherification of Propargylic Esters with Alcohols

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NIAID Data Ecosystem2026-03-08 收录
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Enantioselective propargylic etherification of propargylic esters with not only aliphatic alcohols but also phenols in the presence of a catalytic amount of copper-Pybox complex gives the corresponding propargylic ethers in good to high yields with a high to excellent enantioselectivity (up to 99% ee). The result described here provides the first successful example of enantioselective propargylic etherification

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2016-02-14
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