Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic proxy for EPO-increasing therapies.

Summary statistics for the genome-wide association study meta-analysis of circulating EPO in 6,127 individuals of European and African American descent. Effect sizes are aligned to allele 1. Description of column names: # Marker - this is the marker name; chromosome:position # Allele1 - the first allele for this marker in the first file where it occurs # Allele2 - the second allele for this marker in the first file where it occurs # Freq1 - weighted average of frequency for allele 1 across all studies # FreqSE - corresponding standard error for allele frequency estimate # MinFreq - minimum frequency for allele 1 across all studies # MaxFreq - maximum frequency for allele 1 across all studies # Effect - overall estimated effect size for allele1 # StdErr - overall standard error for effect size estimate # P-value - meta-analysis p-value # Direction - summary of effect direction for each study, with one '+' or '-' per study. Order of the studies is InCHIANTI, BLSA, HealthABC Europeans, PREVEND, HealthABC African Americans # HetISq - I^2 statistic which measures heterogeneity on scale of 0-100% # HetChiSq - chi-squared statistic in simple test of heterogeneity # df - degrees of freedom for heterogeneity statistic # HetPVal - P-value for heterogeneity statistic # TotalSampleSize - overall sample size for that variant in the meta-analysis