Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c
(A) Real time qRT-PCR analysis of mRNA accumulation for Tnfα. Histogram indicates mRNA level of cells treated with PJ34 for 1 h (black), relative to untreated cells (grey, value ~1). Values were norma
PARP15 catalytic domain in complex with OUL218 Descriptor: 4-(1,3-thiazol-5-ylmethoxy)benzamide, DIMETHYL SULFOXIDE, Protein mono-ADP-ribosyltransferase PARP15 Authors: Maksimainen, M.M, Murthy, S, Le