ECP as a treatment for immune checkpoint inhibitor-induced colitis [array]

Mice were treated with DSS and anti-PD1 to induce colitis, comparable to patients suffering from ICI-induced immune-related adverse events. ECP showed beneficial effects in patients. Mice were transplanted with ECP-tretaed cells as treatment and RNA was extracted from colitis tissue to anravel the mechanisms causing the reduction of colitis severity. Mice were treated with DSS and anti-PD1 to induce ICI-mediated colitis. As treatment, mice were transplanted with ECP-treated donor cells. Colitis tissue of control or ECP treated mice were harvested and total RNA was extracted for Microarray analysis.