Synonymous (syn) and non-synonymous (non-syn/NS) changes in E195 whole genome sequencing over the course of fourteen passages of drug selection.

Virus RNA derived from supernatant passages five and fourteen was purified and sequenced, prior to the evolutionary bottleneck and the final passage, as well as a plaque-purified sample virus from passage five. Data reflects the number of discrete changes present within the sample rather than their prevalence within the population. Complete list of changes is provided in S3 Table.