Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
收藏Alliance of Genome Resources2026-08-01 收录
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Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. Here have performed RNAseq on pancreatic islets from C2CD4B-null mice and their littermate controls. C2cd4b-null mice (C2cd4bem2Wtsi) were generated at the International Mouse Phenotyping Consortium (IMPC), using CRISPR/Cas9. RNA from pancreatic islets was isolated and
全基因组关联研究（Genome-Wide Association Studies）显示，靠近VPS13C/C2CD4A/C2CD4B基因座的遗传变异与2型糖尿病的发病风险改变存在关联。本研究对C2CD4B基因敲除小鼠及其同窝对照小鼠的胰腺胰岛开展了RNA测序（RNAseq）。本研究通过CRISPR/Cas9技术，在国际小鼠表型联盟（International Mouse Phenotyping Consortium, IMPC）中构建了C2cd4b基因敲除小鼠（C2cd4bem2Wtsi）。随后分离得到胰腺胰岛的RNA，并
