We generated microglia-like cells (MG) from iPSCs and fibroblast-direct reprogrammed neurons (DRNs), which preserves the aging signatures. We performed RNA seq analysis on microglia which cocultured w
Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly. β-amyloid (Aβ) accumulation in the brain is thought to be a primary event leading to eventual cognitive and motor dysfun