Drug resistance has sharply limited the effectiveness of HIV-1 protease inhibitors in AIDS therapy. It is critically important to understand the basis of this resistance for designing new drugs. We ha

PubMed Central2001-12-18 更新30

NNRTI-resistance results obtained through phenotypic testing, direct sequencing and ultra-deep sequencing (UDPS).

HIV耐药性

超深度测序分析

ETR = etravirine; Direct = Direct Sanger sequencing; UDPS = Ultra-Deep Pyrosequencing; Stan = Stanford; Tibo = Tibotec; Mono = Monogram. *figure beneath amino acid indicate percentage cons

NIAID Data Ecosystem20

Correlation between the phenotypic drug susceptibility and low frequency variants in Taiwanese CRF07_BC early epidemic isolates.

HIV耐药性

低频变异与表型关联

Correlation between the phenotypic drug susceptibility and low frequency variants in Taiwanese CRF07_BC early epidemic isolates.

NIAID Data Ecosystem40

Analysis of pol Gene Heterogeneity, Viral Quasispecies, and Drug Resistance in Individuals Infected with Group O Strains of Human Immunodeficiency Virus Type 1

HIV耐药性

病毒准种

Nucleotide sequences of the reverse transcriptase (RT) coding region have been compared in four new human immunodeficiency virus type 1 (HIV-1) group O isolates. Phylogenetic analysis of this pol regi

PubMed Central20

Next Generation Sequencing Approach to Evaluate HIV Virus in Blood Compartments

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