2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

Nonsense mutations are responsible for about 10% of all genetic diseases, and no dedicated treatment is available for patients. We show that 2,6-diaminopurine efficiently corrects UGA nonsense mutations, with no significant toxicity, by an original mode of action. We also show that 2,6-diaminopurine affect about 3% of the human genome expression.