Developmental Exposure to Endocrine-Disrupting Chemicals Alters Gene Expression in Myometrium of Exposed Animals

The goal of this study was to compare NGS-derived murine myometrial progenitor cell transcriptome profiling (RNA-seq) of an animal model of uterine fibroid tumorigenesis in rats exposed during uterine development to an endocrine-disrupting chemical, diethylstilbestrol (DES) versus vehicle (VEH) control, unexposed animals, to determine the pathways and biological processes, whose gene expression may be altered as a result of the exposure.本研究旨在对比大鼠子宫平滑肌瘤发生动物模型的两组样本的下一代测序（Next Generation Sequencing, NGS）衍生的鼠源子宫肌层祖细胞转录组谱（RNA测序, RNA-seq）：一组为子宫发育阶段暴露于内分泌干扰物己烯雌酚（diethylstilbestrol, DES）的大鼠，另一组为未暴露于溶剂对照（vehicle, VEH）的正常大鼠，以明确暴露诱导基因表达发生改变的信号通路与生物学过程。