Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [array]

ChEBI2013-12-02 更新2026-07-21 收录

白血病发病机制

染色质重塑调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-52231 数据链接链接失效反馈

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [array]

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2013-12-02

Mcm2 promotes stem cell differentiation via its ability to bind H3-H4 (ChIP-Seq)

干细胞分化表观遗传学

染色质重塑调控

Mcm2, a subunit of the Mcm2-7 helicase best known for its role in DNA replication, contains a histone binding motif that facilitates the transfer of parental histone following DNA replication. Here we

NIAID Data Ecosystem50

Gene expression profiling of CA10 and NHD13 murine AML

急性髓系白血病基因表达谱

白血病发病机制

We have compared the gene expression profiles of leukemic tissues in two different mouse models of AML, CALM-AF10 and NHD13, to clincally healthy transgenic and wildtype hematopoetic tissue to identif

Alliance of Genome Resources50

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

NIAID Data Ecosystem30

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia (RNA-seq of KLF6 KO)

造血干细胞表观遗传学

白血病发病机制

Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and trans

NIAID Data Ecosystem50

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [ATAC-seq]

白血病发病机制

表观遗传调控

MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in MGA

NIAID Data Ecosystem30

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [array]

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